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Article

Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice.

Cancer research - 1 Feb 2009

Kuznetsov Sergey G, Haines Diana C, Martin Betty K, Sharan Shyam K

Abstract excerpt

RecA/Rad51 protein family members (Rad51, Rad51b, Rad51c, Rad51d, Xrcc2, and Xrcc3) are essential for DNA repair by homologous recombination, and their role in cancers has been anticipated. Here we provide the first direct evidence for a tumor suppressor function for a member of the Rad51 family....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19155299
DOI: 10.1158/0008-5472.CAN-08-3057
PMCID: PMC2754281

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19155299-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice.PMID 19155299Read ↗

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