Article
Oligomerization of TAS2R bitter taste receptors.
Chemical senses - 1 Jun 2010
Kuhn Christina, Bufe Bernd, Batram Claudia, Meyerhof Wolfgang
Abstract excerpt
A family of 25 G protein-coupled receptors, TAS2Rs, mediates bitter taste in humans. Many of the members of this family are coexpressed in a subpopulation of taste receptor cells on the tongue, thereby allowing the possibility of receptor-receptor interactions with potential influences on their function. In this study, we used several experimental approaches to investigate whether TAS2Rs can form oligomers and if...
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