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Article

TAS2R bitter taste receptors regulate thyroid function.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2015

Clark Adam A, Dotson Cedrick D, Elson Amanda E T, Voigt Anja, Boehm Ulrich, Meyerhof Wolfgang, Steinle Nanette I, Munger Steven D

Abstract excerpt

Dysregulation of thyroid hormones triiodothyronine and thyroxine (T3/T4) can impact metabolism, body composition, and development. Thus, it is critical to identify novel mechanisms that impact T3/T4 production. We found that type 2 taste receptors (TAS2Rs), which are activated by bitter-tasting compounds such as those found in many foods and pharmaceuticals, negatively regulate thyroid-stimulating hormone...

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PMID: 25342133
DOI: 10.1096/fj.14-262246
PMCID: PMC4285546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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