TAS2R bitter taste receptors regulate thyroid function.

doi:10.1096/fj.14-262246

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

TAS2R bitter taste receptors regulate thyroid function.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2015

Clark Adam A, Dotson Cedrick D, Elson Amanda E T, Voigt Anja, Boehm Ulrich, Meyerhof Wolfgang, Steinle Nanette I, Munger Steven D

Abstract excerpt

Dysregulation of thyroid hormones triiodothyronine and thyroxine (T3/T4) can impact metabolism, body composition, and development. Thus, it is critical to identify novel mechanisms that impact T3/T4 production. We found that type 2 taste receptors (TAS2Rs), which are activated by bitter-tasting c...

Topics

Adult
Animals
Calcium
Cell Line
Female
Gene Expression
Humans
Immunohistochemistry
Ligands
Male
Mice
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Polymorphism, Single Nucleotide

Receptors, G-Protein-Coupled

Thyroid Gland

Thyroid Hormones

Thyrotropin

Source

Open in PubMed Open full text

Identifiers

PMID: 25342133
DOI: 10.1096/fj.14-262246
PMCID: PMC4285546

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-25342133-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TAS2R bitter taste receptors regulate thyroid function.PMID 25342133Read ↗

Bitter Taste Receptor Agonists Induce Apoptosis in Papillary Thyroid CancerSemantic proximity Read ↗

Bitter Taste Receptors in Inflammatory and Infectious DiseasesSemantic proximity Read ↗

Bitter Chinese Herbal Medicine Exerts Pharmacological Effects via TAS2Rs: A Systematic Review from Natural Ligands to Therapeutic Potential.Semantic proximity Read ↗

Taste Receptors Mediate Sinonasal Immunity and Respiratory Disease.Semantic proximity Read ↗

The bitter end: T2R bitter receptor agonists elevate nuclear calcium and induce apoptosis in non-ciliated airway epithelial cellsSemantic proximity Read ↗

Role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis.Semantic proximity Read ↗

Expression and Functional Activity of the Human Bitter Taste Receptor TAS2R38 in Human Placental Tissues and JEG-3 Cells.Semantic proximity Read ↗

Genetic, functional, and phenotypic diversity in TAS2R38-mediated bitter taste perception.Semantic proximity Read ↗

Taste receptors influencing effective modalities in human health - A cutting edge update on TAS1R and TAS2R receptor polymorphisms in taste perception and disease risk.Semantic proximity Read ↗

The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance.Semantic proximity Read ↗

Constitutive activity of bitter taste receptors (T2Rs).Semantic proximity Read ↗

Variability in Human Bitter Taste Sensitivity to Chemically Diverse Compounds Can Be Accounted for by Differential TAS2R Activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.