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Article

Methods for meta-analysis of individual participant data from Mendelian randomisation studies with binary outcomes.

Statistical methods in medical research - 1 Feb 2016

Burgess Stephen, Thompson Simon G

Abstract excerpt

Mendelian randomisation is an epidemiological method for estimating causal associations from observational data by using genetic variants as instrumental variables. Typically the genetic variants explain only a small proportion of the variation in the risk factor of interest, and so large sample sizes are required, necessitating data from multiple sources. Meta-analysis based on individual patient data requires...

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PMID: 22717643
DOI: 10.1177/0962280212451882

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