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Article

Endogenous Protein-Protein Interaction Network of the NPC Cholesterol Transporter 1 in the Cerebral Cortex.

Journal of proteome research - 2 Aug 2024

Javanshad Roshan, Nguyen Thu T A, Azaria Ruth D, Li Wenping, Edmison Daisy, Gong Liang-Wei, Gowrishankar Swetha, Lieberman Andrew P, Schultz Mark L, Cologna Stephanie M

Abstract excerpt

NPC intracellular cholesterol transporter 1 (NPC1) is a multipass, transmembrane glycoprotein mostly recognized for its key role in facilitating cholesterol efflux. Mutations in the NPC1 gene result in Niemann-Pick disease, type C (NPC), a fatal, lysosomal storage disease. Due to the progressively expanding implications of NPC1-related disorders, we investigated endogenous NPC1 protein-protein interactions in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38686625
DOI: 10.1021/acs.jproteome.3c00788

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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