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Article

TK.007: A Novel, Codon-Optimized HSVtk(A168H) Mutant for Suicide Gene Therapy

4 Mar 2010

Abstract excerpt

Conditional elimination of infused gene-modified alloreactive T cells, using suicide gene activation, has been shown to be an efficient strategy to abrogate severe graft-versus-host disease (GvHD) in the context of adoptive immunotherapy. To overcome shortcomings of the most widely used suicide gene, wild-type (splice-corrected) herpes simplex virus thymidine kinase (scHSVtk), we generated two new variants: the...

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PMID: 20201626
DOI: 10.1089/hum.2009.042

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