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T-cell suicide gene therapy prompts thymic renewal in adults after hematopoietic stem cell transplantation

18 Jun 2012

Abstract excerpt

The genetic modification of T cells with a suicide gene grants a mechanism of control of adverse reactions, allowing safe infusion after partially incompatible hematopoietic stem cell transplantation (HSCT). In the TK007 clinical trial, 22 adults with hematologic malignancies experienced a rapid and sustained immune recovery after T cell-depleted HSCT and serial infusions of purified donor T cells expressing the...

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PMID: 22709689
DOI: 10.1182/blood-2012-01-405670

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T-cell suicide gene therapy prompts thymic renewal in adults after hematopoietic stem cell transplantationPMID 22709689Read ↗

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IL-7 receptor expression identifies suicide gene–modified allospecific CD8+ T cells capable of self-renewal and differentiation into antileukemia effectorsSemantic proximity Read ↗

Clinical Impact of Suicide Gene Therapy in Allogeneic Hematopoietic Stem Cell TransplantationSemantic proximity Read ↗

Evaluating Thymic Function After Human Hematopoietic Stem Cell Transplantation in the Personalized Medicine EraSemantic proximity Read ↗

T Cell Receptor Excision Circle (TREC) Monitoring after Allogeneic Stem Cell Transplantation; a Predictive Marker for Complications and Clinical OutcomeSemantic proximity Read ↗

The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignanciesSemantic proximity Read ↗

In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells.Semantic proximity Read ↗

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