Article
T cell transduction and suicide with an enhanced mutant thymidine kinase.
Gene therapy - 1 Jun 2002
Qasim W, Thrasher A J, Buddle J, Kinnon C, Black M E, Gaspar H B
Abstract excerpt
Retroviral transfer of Herpes simplex virus thymidine kinase to T cells has been used to confer sensitivity to the antiviral agent ganciclovir. This has allowed therapeutic approaches to be developed in which T cells mediating graft-versus-host disease after bone marrow transplantation can be selectively eliminated by the administration of ganciclovir. Although the strategy has been shown to be generally...
Topics
- Acyclovir
- Antiviral Agents
- Bone Marrow Transplantation
- Cell Line
- Cells, Cultured
- Ganciclovir
- Genetic Therapy
- Genetic Vectors
- Graft vs Host Disease
- Humans
- Leukemia, T-Cell
- Mutation
- Retroviridae
- Simplexvirus
- T-Lymphocytes
- Thymidine Kinase
- Transduction, Genetic