Article
T cell transduction and suicide with an enhanced mutant thymidine kinase.
Gene therapy - 1 Jun 2002
Qasim W, Thrasher A J, Buddle J, Kinnon C, Black M E, Gaspar H B
Abstract excerpt
Retroviral transfer of Herpes simplex virus thymidine kinase to T cells has been used to confer sensitivity to the antiviral agent ganciclovir. This has allowed therapeutic approaches to be developed in which T cells mediating graft-versus-host disease after bone marrow transplantation can be selectively eliminated by the administration of ganciclovir. Although the strategy has been shown to be generally...
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