Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparison of different suicide-gene strategies for the safety improvement of genetically manipulated T cells.

Human gene therapy methods - 1 Dec 2012

Marin Virna, Cribioli Elisabetta, Philip Brian, Tettamanti Sarah, Pizzitola Irene, Biondi Andrea, Biagi Ettore, Pule Martin

Abstract excerpt

Use of adoptive T-cell therapy (ACT) is increasing; however, T-cell therapy can result in severe toxicity. Consequently, several suicide-gene strategies that allow selective destruction of the infused T cells have been described. We compared effectiveness of four such strategies in vitro in Epstein Barr virus (EBV)-cytotoxic T lymphocytes (CTLs). Herpes simplex virus thymidine kinase (HSV-TK), human inducible...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD20
Share to Antigens, CD34

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caspase 9

Share to Ganciclovir

Share to Killer Cells, Natural

Share to Simplexvirus

Share to T-Lymphocytes, Cytotoxic

Share to Thymidine Kinase

Source

Open in PubMed Open full text

Identifiers

PMID: 23186165
DOI: 10.1089/hgtb.2012.050
PMCID: PMC4015080

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparison of different suicide-gene strategies for the safety improvement of genetically manipulated T cells.PMID 23186165Read ↗

Improving the safety of cell therapy products by suicide gene transferSemantic proximity Read ↗

An Improved Bicistronic CD20/tCD34 Vector for Efficient Purification and In Vivo Depletion of Gene-Modified T Cells for Adoptive ImmunotherapySemantic proximity Read ↗

TK.007: A Novel, Codon-Optimized HSVtk(A168H) Mutant for Suicide Gene TherapySemantic proximity Read ↗

Regulated Apoptosis of Genetically Modified Hematopoietic Stem and Progenitor Cells Via an Inducible Caspase-9 Suicide Gene in Rhesus MacaquesSemantic proximity Read ↗

RapaCaspase-9-based suicide gene applied to the safety of IL-1RAP CAR-T cellsSemantic proximity Read ↗

Transduction and selection of human T cells with novel CD34/thymidine kinase chimeric suicide genes for the treatment of graft-versus-host disease.Semantic proximity Read ↗

A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapySemantic proximity Read ↗

Rapacaspase-9-based Suicide Gene Applied to the Safety of Il-1rap Car-t CellsSemantic proximity Read ↗

Characterization of CD20-transduced T lymphocytes as an alternative suicide gene therapy approach for the treatment of graft-versus-host disease.Semantic proximity Read ↗

<i>In vitro</i> assessment of an engineered tBID-based safety switch system in human T lymphocytesSemantic proximity Read ↗

An inducible caspase 9 safety switch for T-cell therapySemantic proximity Read ↗

Inducible Caspase 9 Suicide Gene to Improve the Safety of Allodepleted T Cells after Haploidentical Stem Cell TransplantationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.