Article

A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease

2001-03-01

Abstract excerpt

Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation. One strategy to treat GVHD is to equip donor T cells with a conditional suicide mechanism that can be triggered when GVHD occurs. The herpes simplex virus thymidine kinase (HSV-tk)/ganciclovir system used clinically has several limitations, including immunogenicity and cell cycle dependence. An alternative switch ba...

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Identifiers and source

Literature Corpus work: 13fd204d-3100-5d72-afce-ef1ccdbb1c82
DOI: 10.1182/blood.v97.5.1249.h8001249_1249_1257

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