Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Herpes Simplex Virus Thymidine Kinase Gene Transfer for Controlled Graft-versus-Host Disease and Graft-versus-Leukemia: Clinical Follow-up and Improved New Vectors

10 Oct 1998

Abstract excerpt

We previously demonstrated that severe graft-versus-host disease (GvHD), associated with the therapeutic infusion of donor lymphocytes after allogeneic marrow transplantation (BMT), can be efficiently controlled by the SFCMM-2-mediated expression of the herpes simplex virus thymidine kinase (HSV-tk) suicide gene into the allogeneic lymphocytes. This was achieved by selective elimination of transduced lymphocytes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Herpesvirus Infections and Treatments
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9794208
DOI: 10.1089/hum.1998.9.15-2243

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Herpes Simplex Virus Thymidine Kinase Gene Transfer for Controlled Graft-versus-Host Disease and Graft-versus-Leukemia: Clinical Follow-up and Improved New VectorsPMID 9794208Read ↗

Molecular mechanism for ganciclovir resistance in human T lymphocytes transduced with retroviral vectors carrying the herpes simplex virus thymidine kinase geneSemantic proximity Read ↗

Transduction and selection of human T cells with novel CD34/thymidine kinase chimeric suicide genes for the treatment of graft-versus-host disease.Semantic proximity Read ↗

Genetically modified and unmodified cellular approaches to enhance graft versus leukemia effect, without increasing graft versus host disease: the use of allogeneic cytokine-induced killer cellsSemantic proximity Read ↗

"Suicide" gene for the control of graft-versus-host disease.Semantic proximity Read ↗

Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graftSemantic proximity Read ↗

TK.007: A Novel, Codon-Optimized HSVtk(A168H) Mutant for Suicide Gene TherapySemantic proximity Read ↗

Use of TK-cells in haploidentical hematopoietic stem cell transplantationSemantic proximity Read ↗

The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignanciesSemantic proximity Read ↗

T cell transduction and suicide with an enhanced mutant thymidine kinase.Semantic proximity Read ↗

Graft-versus-leukemia reactions in allogeneic chimerasSemantic proximity Read ↗

A Fas-based suicide switch in human T cells for the treatment of graft-versus-host diseaseSemantic proximity Read ↗

A Fas-based suicide switch in human T cells for the treatment of graft-versus-host diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.