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Article

"Suicide" gene for the control of graft-versus-host disease.

Current opinion in hematology - 1 Nov 1998

Tiberghien P

Abstract excerpt

Specific and conditional in vivo ablation of alloreactive donor T cells after allogeneic hematopoietic stem cell transplantation could significantly contribute to preventing and treating graft-versus-host disease (GVHD). The use of donor T cells expressing a "suicide" gene such as the thymidine kinase gene of the herpes simplex virus 1 (HS-tk) has the potential of achieving such a goal. Ex vivo...

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Source

Identifiers

PMID: 9814659
DOI: 10.1097/00062752-199811000-00021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

"Suicide" gene for the control of graft-versus-host disease.PMID 9814659Read ↗

Use of TK-cells in haploidentical hematopoietic stem cell transplantationSemantic proximity Read ↗

Clinical Impact of Suicide Gene Therapy in Allogeneic Hematopoietic Stem Cell TransplantationSemantic proximity Read ↗

Suicide Gene Therapy to Increase the Safety of Chimeric Antigen Receptor-Redirected T LymphocytesSemantic proximity Read ↗

Adoptive immunotherapy with genetically modified lymphocytes in allogeneic stem cell transplantationSemantic proximity Read ↗

The Suicide Gene Therapy Challenge: How to Improve a Successful Gene Therapy ApproachSemantic proximity Read ↗

The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignanciesSemantic proximity Read ↗

Control of graft-versus-host disease with maintenance of the graft-versus-leukemia effect in a murine allogeneic transplant model using retrovirally transduced murine suicidal lymphocytes.Semantic proximity Read ↗

A Fas-based suicide switch in human T cells for the treatment of graft-versus-host diseaseSemantic proximity Read ↗

T-cell suicide gene therapy prompts thymic renewal in adults after hematopoietic stem cell transplantationSemantic proximity Read ↗

T cell transduction and suicide with an enhanced mutant thymidine kinase.Semantic proximity Read ↗

Improving the safety of cell therapy products by suicide gene transferSemantic proximity Read ↗

A Fas-based suicide switch in human T cells for the treatment of graft-versus-host diseaseSemantic proximity Read ↗

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