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Article

Use of TK-cells in haploidentical hematopoietic stem cell transplantation

22 Aug 2012

Abstract excerpt

PURPOSE OF REVIEW: Preserving the beneficial effects of donor T cells against tumor and pathogens while avoiding noxious graft-versus-host disease (GvHD) is the 'holy grail' of allogeneic hematopoietic stem cell transplantation (HSCT). The suicide gene strategy allows the selective elimination of genetically modified donor T cells during GvHD. This review summarizes the results obtained in recent years in the...

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PMID: 22918402
DOI: 10.1097/moh.0b013e32835822f5

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