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Article

Unperturbed Immune Function despite Mutation of C-Terminal Tyrosines in Syk Previously Implicated in Signaling and Activity Regulation.

Molecular and cellular biology - 1 Nov 2017

Weis Vanessa, Königsberger Sebastian, Amler Susanne, Wienands Jürgen, Kiefer Friedemann

Abstract excerpt

The nonreceptor tyrosine kinase Syk, a central regulator of immune cell differentiation and activation, is a promising drug target for treatment of leukemia and allergic and inflammatory diseases. The clinical failure of Syk inhibitors underscores the importance of understanding the regulation of Syk function and activity. A series of previous studies emphasized the importance of three C-terminal tyrosines in Syk...

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Identifiers

PMID: 28760774
DOI: 10.1128/MCB.00216-17
PMCID: PMC5640812

Genes

SYK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Unperturbed Immune Function despite Mutation of C-Terminal Tyrosines in Syk Previously Implicated in Signaling and Activity Regulation.PMID 28760774Read ↗

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