Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Syk inhibition limits autoimmunity and abnormal B cell phenotype and function in mice with B cell-specific TRAF3 deficiency.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2026

Hornick Emma L, Oxley Kyp, Debreceni Ivy L, Wieting Nathaniel, Ybarra Tiffany K, Hostager Bruce S, Lieberman Scott M, Bishop Gail A

Abstract excerpt

Autoimmune disorders reduce quality of life and lifespan and can increase B cell lymphoma risk. The adaptor protein TRAF3 regulates B cell survival, activation, and differentiation by restraining signaling through Toll-like receptors, tumor necrosis factor (TNF) receptor superfamily members, and the B cell antigen receptor-pathways linked to autoimmunity and lymphoma. Mice lacking TRAF3 in B cells (B-Traf3-/-)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminopyridines
Share to Autoantibodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autoimmunity

Share to Morpholines

Share to Oxazines

Share to Pyridines

Share to Pyrimidines

Share to Syk Kinase

Source

Open in PubMed Open full text

Identifiers

PMID: 42026764
DOI: 10.1093/jimmun/vkag049
PMCID: PMC13105860

Genes

TRAF3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Syk inhibition limits autoimmunity and abnormal B cell phenotype and function in mice with B cell-specific TRAF3 deficiency.PMID 42026764Read ↗

TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cellsSemantic proximity Read ↗

Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations.Semantic proximity Read ↗

The role of Bruton’s tyrosine kinase in autoimmunity and implications for therapySemantic proximity Read ↗

ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiotaSemantic proximity Read ↗

Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice.Semantic proximity Read ↗

Reduced Function of the Adaptor SH2B3 Promotes T1D via Altered Cytokine-Regulated, T-Cell-Intrinsic Immune Tolerance.Semantic proximity Read ↗

STAT3 signaling in immunity.Semantic proximity Read ↗

SOCS, Inflammation, and AutoimmunitySemantic proximity Read ↗

Reduced function of the adaptor SH2B3 promotes T1D via altered gc cytokine-regulated, T cell intrinsic immune toleranceSemantic proximity Read ↗

Whole-Genome Expression Profiling in Skin Reveals SYK As a Key Regulator of Inflammation in Experimental Epidermolysis Bullosa AcquisitaSemantic proximity Read ↗

Nuclear TRAF3 is a negative regulator of CREB in B cellsSemantic proximity Read ↗

Research progress of SOCS in autoimmune diseases: mechanisms and therapeutic implicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.