Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer.

doi:10.1158/0008-5472.CAN-09-3575

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Article

Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer.

Cancer research - 15 Mar 2010

Koutros Stella, Schumacher Fredrick R, Hayes Richard B, Ma Jing, Huang Wen-Yi, Albanes Demetrius, Canzian Federico, Chanock Stephen J, Crawford E David, Diver W Ryan, Feigelson Heather Spencer, Giovanucci Edward, Haiman Christopher A, Henderson Brian E, Hunter David J, Kaaks Rudolf, Kolonel Laurence N, Kraft Peter, Le Marchand Loïc, Riboli Elio, Siddiq Afshan, Stampfer Mier J, Stram Daniel O, Thomas Gilles, Travis Ruth C, Thun Michael J, Yeager Meredith, Berndt Sonja I

Abstract excerpt

The phosphatidylinositol 3-kinase (PI3K) pathway regulates various cellular processes, including cellular proliferation and intracellular trafficking, and may affect prostate carcinogenesis. Thus, we explored the association between single-nucleotide polymorphisms (SNP) in PI3K genes and prostate cancer. Pooled data from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium were examined for...

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PMID: 20197460
DOI: 10.1158/0008-5472.CAN-09-3575
PMCID: PMC2840184

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