Article
PI3K signaling pathway is activated by PIK3CA mRNA overexpression and copy gain in prostate tumors, but PIK3CA, BRAF, KRAS and AKT1 mutations are infrequent events.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2011
Agell Laia, Hernández Silvia, Salido Marta, de Muga Silvia, Juanpere Nuria, Arumí-Uria Montserrat, Menendez Silvia, Lorenzo Marta, Lorente José A, Serrano Sergio, Lloreta Josep
Abstract excerpt
The phosphatidylinositol 3-kinase (PI3K)-AKT and RAS-MAPK pathways are deregulated in a wide range of human cancers by gain or loss of function in several of their components. Our purpose has been to identify genetic alterations in members of these pathways in prostate cancer. A total of 102 prostate tumors, 79 from prostate cancer alone (group G1) and 23 from bladder and prostate cancer patients (G2), are the...
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