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Article

Stress fiber-based movement of Shigella flexneri within cells.

Infection and immunity - 1 May 1991

Vasselon T, Mounier J, Prevost M C, Hellio R, Sansonetti P J

Abstract excerpt

icsA (virG), a gene located on pWR100, the virulence plasmid of Shigella flexneri serotype 5 (M90T), encodes a 120-kDa outer membrane protein. This protein promotes a random intracellular movement of the bacteria and leads to the infection of adjacent cells by the formation of protrusions. This movement, which involves the nucleation, polymerization, and subsequent polarization of actin, is referred to as the Ics...

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Identifiers

PMID: 2019438
DOI: 10.1128/iai.59.5.1723-1732.1991
PMCID: PMC257908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stress fiber-based movement of Shigella flexneri within cells.PMID 2019438Read ↗

Actin-based motility is sufficient for bacterial membrane protrusion formation and host cell uptake.Semantic proximity Read ↗

The use of Shigella flexneri to study bacterial cell biology during infection of host cellsSemantic proximity Read ↗

<i>Shigella flexneri</i> disruption of host cell-cell tension promotes intercellular spreadSemantic proximity Read ↗

Multicopy icsA is able to suppress the virulence defect caused by the wzz(SF) mutation in Shigella flexneri.Semantic proximity Read ↗

Myosin IIA is essential for Shigella flexneri cell-to-cell spread.Semantic proximity Read ↗

Outer membrane protein A (OmpA): a new player in shigella flexneri protrusion formation and inter-cellular spreading.Semantic proximity Read ↗

Quantitative analysis of P lasmodiumookinete motion in three dimensions suggests a critical role for cell shape in the biomechanics of malaria parasite gliding motilitySemantic proximity Read ↗

Disruption of IcsP, the major Shigella protease that cleaves IcsA, accelerates actin-based motility.Semantic proximity Read ↗

icsB: a Shigella flexneri virulence gene necessary for the lysis of protrusions during intercellular spread.Semantic proximity Read ↗

Cleavage of Shigella surface protein VirG occurs at a specific site, but the secretion is not essential for intracellular spreading.Semantic proximity Read ↗

Modulation of an outer membrane protease contributes to the virulence defect of Shigella flexneri strains carrying a mutation in the virK locus.Semantic proximity Read ↗

Phosphorylation of IcsA by cAMP-dependent protein kinase and its effect on intracellular spread of Shigella flexneri.Semantic proximity Read ↗

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