Article
Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases.
Annals of the rheumatic diseases - 1 Apr 2017
Hinks A, Bowes J, Cobb J, Ainsworth H C, Marion M C, Comeau M E, Sudman M, Han B, Becker M L, Bohnsack J F, de Bakker P I W, Haas J P, Hazen M, Lovell D J, Nigrovic P A, Nordal E, Punnaro M, Rosenberg A M, Rygg M, Smith S L, Wise C A, Videm V, Wedderburn L R, Yarwood A, Yeung R S M, Prahalad S, Langefeld C D, Raychaudhuri S, Thompson S D, Thomson W
Abstract excerpt
OBJECTIVES: Juvenile idiopathic arthritis (JIA) is a heterogeneous group of diseases, comprising seven categories. Genetic data could potentially be used to help redefine JIA categories and improve the current classification system. The human leucocyte antigen (HLA) region is strongly associated with JIA. Fine-mapping of the region was performed to look for similarities and differences in HLA associations between...
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