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Article

Egr1 Promotes Growth and Survival of Prostate Cancer Cells

28 Mar 2003

Abstract excerpt

In the majority of aggressive tumorigenic prostate cancer cells, the transcription factor Egr1 is overexpressed. We provide new insights of Egr1 involvement in proliferation and survival of TRAMP C2 prostate cancer cells by the identification of several new target genes controlling growth, cell cycle progression, and apoptosis such as cyclin D2, P19ink4d, and Fas. Egr1 regulation of these genes, identified by...

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PMID: 12556466
DOI: 10.1074/jbc.m210279200

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