Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip

Abstract excerpt

BACKGROUND: UV irradiation activates the epidermal growth factor receptor, induces Egr1 expression and promotes apoptosis in a variety of cell types. We examined the hypothesis that Egr1 regulates genes that mediate this process by use of a chip-on-chip protocol in human tumorigenic prostate M12 cells. RESULTS: UV irradiation led to significant binding of 288 gene promoters by Egr1. A major functional subgroup...

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