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Article

FGFR1 is required for the development of the auditory sensory epithelium.

Neuron - 15 Aug 2002

Pirvola Ulla, Ylikoski Jukka, Trokovic Ras, Hébert Jean M, McConnell Susan K, Partanen Juha

Abstract excerpt

The mammalian auditory sensory epithelium, the organ of Corti, comprises the hair cells and supporting cells that are pivotal for hearing function. The origin and development of their precursors are poorly understood. Here we show that loss-of-function mutations in mouse fibroblast growth factor receptor 1 (Fgfr1) cause a dose-dependent disruption of the organ of Corti. Full inactivation of Fgfr1 in the inner ear...

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Source

Identifiers

PMID: 12194867
DOI: 10.1016/s0896-6273(02)00824-3

Genes

FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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