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Article

HAMLET effect on cell death and mitochondrial respiration in colorectal cancer cell lines with KRAS/BRAF mutations.

Journal of cancer research and clinical oncology - 1 Sept 2023

Žilinskas Justas, Stukas Darius, Jasukaitienė Aldona, Šapauskienė Jurgita, Banienė Rasa, Trumbeckaitė Sonata, Švagždys Saulius, Cicciu Marco, Dambrauskas Žilvinas, Gulbinas Antanas, Tamelis Algimantas

Abstract excerpt

PURPOSE: Treatment of advanced colorectal cancer (CRC) depends on the correct selection of personalized strategies. HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a natural proteolipid milk compound that might serve as a novel cancer prevention and therapy candidate. Our purpose was to investigate HAMLET effect on viability, death pathway and mitochondrial bioenergetics of CRC cells with different...

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Identifiers

PMID: 37099199
DOI: 10.1007/s00432-023-04777-0
PMCID: PMC10374481

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