Article
Alpha-lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells).
Protein science : a publication of the Protein Society - 1 Dec 2003
Svensson Malin, Fast Jonas, Mossberg Ann-Kristin, Düringer Caroline, Gustafsson Lotta, Hallgren Oskar, Brooks Charles L, Berliner Lawrence, Linse Sara, Svanborg Catharina
Abstract excerpt
HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a complex of human alpha-lactalbumin and oleic acid (C18:1:9 cis) that kills tumor cells by an apoptosis-like mechanism. Previous studies have shown that a conformational change is required to form HAMLET from alpha-lactalbumin, and that a partially unfolded conformation is maintained in the HAMLET complex. This study examined if unfolding of...
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