Article
Expression and genotype-dependent catalytic activity of N-acetyltransferase 2 (NAT2) in human peripheral blood mononuclear cells and its modulation by Sirtuin 1.
Biochemical pharmacology - 1 Oct 2018
Salazar-González Raúl A, Turiján-Espinoza Eneida, Hein David W, Milán-Segovia Rosa C, Uresti-Rivera Edith E, Portales-Pérez Diana P
Abstract excerpt
N-acetyltransferase 2 (NAT2) catalyzes the biotransformation of numerous arylamine and hydrazine drugs and carcinogens. Genetic polymorphisms of NAT2 modify drug efficacy and toxicity and susceptibility to diseases such as cancer and type 2 diabetes. Expression of NAT2 has been documented in the liver and gastrointestinal tract but not in other tissues. Deacetylation of cytosolic proteins by sirtuins is a...
Topics
- Adult
- Arylamine N-Acetyltransferase
- Female
- Gene Expression Regulation
- Genotype
- Humans
- Isoniazid
- Leukocytes, Mononuclear
- Male
- RNA, Messenger
- Sirtuin 1
- Young Adult