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Article

Expression and genotype-dependent catalytic activity of N-acetyltransferase 2 (NAT2) in human peripheral blood mononuclear cells and its modulation by Sirtuin 1.

Biochemical pharmacology - 1 Oct 2018

Salazar-González Raúl A, Turiján-Espinoza Eneida, Hein David W, Milán-Segovia Rosa C, Uresti-Rivera Edith E, Portales-Pérez Diana P

Abstract excerpt

N-acetyltransferase 2 (NAT2) catalyzes the biotransformation of numerous arylamine and hydrazine drugs and carcinogens. Genetic polymorphisms of NAT2 modify drug efficacy and toxicity and susceptibility to diseases such as cancer and type 2 diabetes. Expression of NAT2 has been documented in the liver and gastrointestinal tract but not in other tissues. Deacetylation of cytosolic proteins by sirtuins is a...

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Identifiers

PMID: 30149019
DOI: 10.1016/j.bcp.2018.08.034
PMCID: PMC6350916

Genes

NAT2
SIRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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