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Article

Evaluation of hepatic glutathione transferase Mu 1 and Theta 1 activities in humans and mice using genotype information.

Drug metabolism and disposition: the biological fate of chemicals - 1 Mar 2012

Arakawa Shingo, Fujimoto Kazunori, Kato Ayako, Endo Seiko, Fukahori Aiko, Shinagawa Akira, Fischer Thomas, Mueller Juergen, Takasaki Wataru

Abstract excerpt

We investigated the impact of glutathione transferases Mu 1 (GSTM1)- and glutathione transferase Theta 1 (GSTT1)-null genotypes on hepatic GST activities in humans and compared the results with those of Gstm1- and Gstt1-null mice. In liver with GSTM1/Gstm1-null genotype, GST activity toward p-nitrobenzyl chloride (NBC) was significantly decreased in both humans and mice. In addition, in liver with...

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Genotype
Glutathione Transferase
Liver
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Substrate Specificity

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Identifiers

PMID: 22170331
DOI: 10.1124/dmd.111.042911

Genes

GSTM1
GSTT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Evaluation of hepatic glutathione transferase Mu 1 and Theta 1 activities in humans and mice using genotype information.PMID 22170331Read ↗

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