Article
Dysbindin genotype and negative symptoms in schizophrenia.
The American journal of psychiatry - 1 Mar 2006
DeRosse Pamela, Funke Birgit, Burdick Katherine E, Lencz Todd, Ekholm Jenny M, Kane John M, Kucherlapati Raju, Malhotra Anil K
Abstract excerpt
OBJECTIVE: Converging evidence has demonstrated an association between variants in the dysbindin gene (DTNBP1) and schizophrenia. Recently, a DTNBP1 risk haplotype, associated with both schizophrenia and neurocognitive dysfunction, has been identified. Because neurocognitive dysfunction is commonly accompanied by negative symptoms (avolition, alogia, and affective flattening) in schizophrenia, the authors...
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