Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The PAF1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish.

Developmental biology - 1 May 2010

Nguyen Catherine T, Langenbacher Adam, Hsieh Michael, Chen Jau-Nian

Abstract excerpt

Leo1 is a component of the Polymerase-Associated Factor 1 (PAF1) complex, an evolutionarily conserved protein complex involved in gene transcription regulation and chromatin remodeling. The role of leo1 in vertebrate embryogenesis has not previously been examined. Here, we report that zebrafish l...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to DNA-Directed RNA Polymerases
Share to Heart

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neural Crest

Share to Nuclear Proteins

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 20178782
DOI: 10.1016/j.ydbio.2010.02.020
PMCID: PMC2854236

Genes

PAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20178782-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The PAF1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish.PMID 20178782Read ↗

Paf1 complex homologues are required for Notch-regulated transcription during somite segmentation.Semantic proximity Read ↗

Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development.Semantic proximity Read ↗

Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.Semantic proximity Read ↗

Antagonistic regulation of PAF1C and p-TEFb is required for oligodendrocyte differentiation.Semantic proximity Read ↗

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defectsSemantic proximity Read ↗

Lef1 plays a role in patterning the mesoderm and ectoderm in Xenopus tropicalis.Semantic proximity Read ↗

aldh7a1 regulates eye and limb development in zebrafish.Semantic proximity Read ↗

GLE1 dysfunction compromises cellular homeostasis, spatial organization, and peripheral axon branchingSemantic proximity Read ↗

The PAF1 complex is involved in embryonic epidermal morphogenesis in Caenorhabditis elegans.Semantic proximity Read ↗

oto is a homeotic locus with a role in anteroposterior development that is partially redundant with Lim1.Semantic proximity Read ↗

Impaired neural development in a zebrafish model for Lowe syndromeSemantic proximity Read ↗

Mutation of zebrafish caf-1b results in S phase arrest, defective differentiation, and p53-mediated apoptosis during organogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.