Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

aldh7a1 regulates eye and limb development in zebrafish.

PloS one - 1 Jan 2014

Babcock Holly E, Dutta Sunit, Alur Ramakrishna P, Brocker Chad, Vasiliou Vasilis, Vitale Susan, Abu-Asab Mones, Brooks Brian P

Abstract excerpt

Uveal coloboma is a potentially blinding congenital ocular malformation caused by failure of the optic fissure to close during development. Although mutations in numerous genes have been described, these account for a minority of cases, complicating molecular diagnosis and genetic counseling. Here we describe a key role of aldh7a1 as a gene necessary for normal eye development. We show that morpholino knockdown...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehyde Dehydrogenase
Share to Embryo, Nonmammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Development

Share to Extremities

Share to Gene Knockdown Techniques

Share to Tretinoin

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25004007
DOI: 10.1371/journal.pone.0101782
PMCID: PMC4086958

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

aldh7a1 regulates eye and limb development in zebrafish.PMID 25004007Read ↗

Zfp503/Nlz2 is Required for RPE Differentiation and Optic Fissure ClosureSemantic proximity Read ↗

Transcriptome profiling of zebrafish optic fissure fusionSemantic proximity Read ↗

Identification of novel coloboma candidate genes through conserved gene expression analyses across four vertebrate speciesSemantic proximity Read ↗

Morphogenetic defects underlie Superior Coloboma, a newly identified closure disorder of the dorsal eyeSemantic proximity Read ↗

Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis.Semantic proximity Read ↗

Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closureSemantic proximity Read ↗

Genetics Underlying the Interactions between Neural Crest Cells and Eye DevelopmentSemantic proximity Read ↗

The zebrafish mutant bumper shows a hyperproliferation of lens epithelial cells and fibre cell degeneration leading to functional blindness.Semantic proximity Read ↗

Molecular and developmental mechanisms of anterior segment dysgenesis.Semantic proximity Read ↗

Porcn is essential for growth and invagination of the mammalian optic cupSemantic proximity Read ↗

ALDH1A3 loss of function causes bilateral anophthalmia/microphthalmia and hypoplasia of the optic nerve and optic chiasmSemantic proximity Read ↗

Conserved genetic pathways associated with microphthalmia, anophthalmia, and colobomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.