Article

GLE1 dysfunction compromises cellular homeostasis, spatial organization, and peripheral axon branching

2024-10-16

Abstract excerpt

The GLE1 protein is an enigmatic factor of RNA processing, associated with multiple developmental disorders including lethal congenital contracture syndrome 1 (LCCS1). Using in vivo genetic engineering to study disturbed GLE1 functions under physiological conditions we demonstrate that inactivation of Gle1 impedes cellular function and organization and causes pre-gastrulation lethality due to defects in adhesion...

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Literature Corpus work: 9f63ee2d-318e-5960-af3c-9a20a8c91c62
DOI: 10.1101/2024.10.14.618161

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