Article
Neuroprotective and neurotoxic phenotypes of activated microglia in neonatal mice with respective MPTP- and ethanol-induced brain injury.
Neuro-degenerative diseases - 1 Jan 2010
Sawada Hirohide, Suzuki Hiromi, Nagatsu Toshiharu, Sawada Makoto
Abstract excerpt
Activated microglia play important roles in the inflammatory process and progression in Parkinson's disease. These cells produce various cytokines, nitric oxide, and neurotrophins, which are pleiotropic in their action, i.e., neuroprotective or neurotoxic. In an in vivo study on a mouse model wit...
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