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Article

Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Oct 2010

Zschenker Oliver, Raabe Annette, Boeckelmann Inga Kathleen, Borstelmann Sonko, Szymczak Silke, Wellek Stefan, Rades Dirk, Hoeller Ulrike, Ziegler Andreas, Dikomey Ekkehard, Borgmann Kerstin

Abstract excerpt

PURPOSE: To examine the association of polymorphisms in ATM (codon 158), GSTP1 (codon 105), SOD2 (codon 16), TGFB1 (position -509), XPD (codon 751), and XRCC1 (codon 399) with fibrosis and also individual radiosensitivity. METHODS AND MATERIALS: Retrospective analysis with 69 breast cancer patients treated with breast-conserving radiotherapy; total dose delivered was restricted to vary between 54 and 55Gy....

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Identifiers

PMID: 20170971
DOI: 10.1016/j.radonc.2010.01.016

Genes

ATM
GSTP1
SOD2
TGFB1
XRCC1

Provenance

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