Article
Interlaboratory diagnostic validation of conformation-sensitive capillary electrophoresis for mutation scanning.
Clinical chemistry - 1 Apr 2010
Mattocks Christopher J, Watkins Gemma, Ward Daniel, Janssens Tom, Bosgoed Ermanno A J, van der Donk Kim, Ligtenberg Marjolijn J, Pot Bruno, Theelen Joop, Cross Nicholas C P, Scheffer Hans, Matthijs Gert
Abstract excerpt
BACKGROUND: Indirect alternatives to sequencing as a method for mutation scanning are of interest to diagnostic laboratories because they have the potential for considerable savings in both time and costs. Ideally, such methods should be simple, rapid, and highly sensitive, and they should be validated formally to a very high standard. Currently, most reported methods lack one or more of these characteristics. We...
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