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Article

High throughput DNA sequence variant detection by conformation sensitive capillary electrophoresis and automated peak comparison.

Genomics - 1 Mar 2006

Davies Helen, Dicks Ed, Stephens Philip, Cox Charles, Teague Jon, Greenman Chris, Bignell Graham, O'meara Sarah, Edkins Sarah, Parker Adrian, Stevens Claire, Menzies Andrew, Blow Matt, Bottomley Bill, Dronsfield Mark, Futreal P Andrew, Stratton Michael R, Wooster Richard

Abstract excerpt

We report the development of a heteroduplex-based mutation detection method using multicapillary automated sequencers, known as conformation-sensitive capillary electrophoresis (CSCE). Our optimized CSCE protocol detected 93 of 95 known base substitution sequence variants. Since the optimization of the method, we have analyzed 215 Mb of DNA and identified 3397 unique variants. An analysis of this data set...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16406726
DOI: 10.1016/j.ygeno.2005.11.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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