Article
BRCA1 mutation screening using restriction endonuclease fingerprinting-single-strand conformation polymorphism in an automated capillary electrophoresis system.
Electrophoresis - 1 Dec 2002
Kringen Pedro, Egedal Sidsel, Pedersen Jan C, Harbitz Thorstein B, Tveit Kjell M, Berg Kåre, Børresen-Dale Anne-Lise, Andersen Tone I
Abstract excerpt
Efficient mutation scanning techniques are needed for the rapid detection of novel disease-associated mutations and rare-sequence variants of putative importance. The large size of the breast cancer 1 gene (BRCA1) and the many mutations found throughout its entire coding sequence make screening for mutations in this gene particularly challenging. We have developed a method for screening exon 11 of the BRCA1 gene...
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