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Design and Analytical Validation of Clinical DNA Sequencing Assays

30 Dec 2011

Abstract excerpt

CONTEXT: DNA sequencing is the method of choice for mutation detection in many genes. OBJECTIVES: To demonstrate the analytical accuracy and reliability of DNA sequencing assays developed in clinical laboratories. Only general guidelines exist for the validation of these tests. We provide examples of assay validation strategies for DNA sequencing tests. DESIGN: We discuss important design and validation...

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Identifiers

PMID: 22208486
DOI: 10.5858/arpa.2010-0623-oa

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