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Article

Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Feb 2010

Kolber Benedict J, Boyle Maureen P, Wieczorek Lindsay, Kelley Crystal L, Onwuzurike Chiamaka C, Nettles Sabin A, Vogt Sherri K, Muglia Louis J

Abstract excerpt

During development, early-life stress, such as abuse or trauma, induces long-lasting changes that are linked to adult anxiety and depressive behavior. It has been postulated that altered expression of corticotropin-releasing hormone (CRH) can at least partially account for the various effects of stress on behavior. In accord with this hypothesis, evidence from pharmacological and genetic studies has indicated the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20164342
DOI: 10.1523/JNEUROSCI.4470-09.2010
PMCID: PMC2969849

Genes

CRH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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