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Article

Childhood adversity and allostatic overload of the hypothalamic-pituitary-adrenal axis: a vulnerability model for depressive disorders.

Development and psychopathology - 1 Nov 2011

Wilkinson Paul O, Goodyer Ian M

Abstract excerpt

Childhood adversity is associated with increased risk for onset of depressive episodes. This review will present evidence that allostatic overload of the hypothalamic-pituitary-adrenal axis (HPAA) partially mediates this association. The HPAA is the physiological system that regulates levels of the stress hormone cortisol. First, data from animals and humans has shown that early environmental adversity is...

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PMID: 22018079
DOI: 10.1017/S0954579411000472

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