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Article

Mutations affecting RNA polymerase I-stimulated exchange and rDNA recombination in yeast.

Genetics - 1 Jan 1991

Lin Y H, Keil R L

Abstract excerpt

HOT1 is a cis-acting recombination-stimulatory sequence isolated from the rDNA repeat unit of yeast. The ability of HOT1 to stimulate mitotic exchange appears to depend on its ability to promote high levels of RNA polymerase I transcription. A qualitative colony color sectoring assay was developed to screen for trans-acting mutations that alter the activity of HOT1. Both hypo-recombination and hyper-recombination...

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Source

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Identifiers

PMID: 2016045
DOI: 10.1093/genetics/127.1.31
PMCID: PMC1204309

Genes

RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Mutations affecting RNA polymerase I-stimulated exchange and rDNA recombination in yeast.PMID 2016045Read ↗

Genetic control of RNA polymerase I-stimulated recombination in yeast.Semantic proximity Read ↗

A chromosome containing HOT1 preferentially receives information during mitotic interchromosomal gene conversion.Semantic proximity Read ↗

Gene conversion tracts stimulated by HOT1-promoted transcription are long and continuous.Semantic proximity Read ↗

HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene.Semantic proximity Read ↗

DEG1, encoding the tRNA:pseudouridine synthase Pus3p, impacts HOT1-stimulated recombination in Saccharomyces cerevisiae.Semantic proximity Read ↗

The rad52-Y66A allele alters the choice of donor template during spontaneous chromosomal recombination.Semantic proximity Read ↗

Characterization of mutations that suppress the temperature-sensitive growth of the hpr1 delta mutant of Saccharomyces cerevisiae.Semantic proximity Read ↗

The RAD50 gene, a member of the double strand break repair epistasis group, is not required for spontaneous mitotic recombination in yeast.Semantic proximity Read ↗

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Ribosomal DNA replication fork barrier and HOT1 recombination hot spot: shared sequences but independent activities.Semantic proximity Read ↗

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