Article
Genetic control of RNA polymerase I-stimulated recombination in yeast.
Genetics - 1 Sept 1990
Zehfus B R, McWilliams A D, Lin Y H, Hoekstra M F, Keil R L
Abstract excerpt
We examined the genetic control of the activity of HOT1, a cis-acting recombination-stimulatory sequence of Saccharomyces cerevisiae. Mutations in RAD1 and RAD52 decrease the ability of HOT1 to stimulate intrachromosomal recombination while mutations in RAD4 and RAD50 do not affect HOT1 activity. In rad1 delta strains, the stimulation of excisive recombination by HOT1 is decreased while the rate of gene...
Topics
- Blotting, Southern
- Diploidy
- Genes, Fungal
- Mutation
- Phenotype
- RNA Polymerase I
- Recombination, Genetic
- Regulatory Sequences, Nucleic Acid
- Saccharomyces cerevisiae