Article
DEG1, encoding the tRNA:pseudouridine synthase Pus3p, impacts HOT1-stimulated recombination in Saccharomyces cerevisiae.
Molecular genetics and genomics : MGG - 1 Dec 2005
Hepfer C E, Arnold-Croop S, Fogell H, Steudel K G, Moon M, Roff A, Zaikoski S, Rickman A, Komsisky K, Harbaugh D L, Lang G I, Keil R L
Abstract excerpt
In Saccharomyces cerevisiae, HOT1-stimulated recombination has been implicated in maintaining homology between repeated ribosomal RNA genes. The ability of HOT1 to stimulate genetic exchange requires RNA polymerase I transcription across the recombining sequences. The trans-acting nuclear mutation hrm3-1 specifically reduces HOT1-dependent recombination and prevents cell growth at 37 degrees . The HRM3 gene is...
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