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Article

Meiosis-specific double-strand DNA breaks at the HIS4 recombination hot spot in the yeast Saccharomyces cerevisiae: control in cis and trans.

Molecular and cellular biology - 1 Mar 1995

Fan Q, Xu F, Petes T D

Abstract excerpt

The region of Saccharomyces cerevisiae chromosome III located between the 5' end of the HIS4 gene and the 3' end of the adjacent BIK1 gene has a very high level of meiotic recombination. In wild-type strains, a meiosis-specific double-strand DNA break occurs in the hot spot region. This break is absent in strains in which the transcription factors Rap1p, Bas1p, and Bas2p cannot bind to the region upstream of...

Topics

Chromosome Aberrations
Chromosomes, Fungal
DNA, Fungal
Genotype
Haploidy
Meiosis
Plasmids
Recombination, Genetic
Regulatory Sequences, Nucleic Acid
Saccharomyces cerevisiae
Species Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7862159
DOI: 10.1128/MCB.15.3.1679
PMCID: PMC230392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7862159-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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