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Article

Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy.

Aging - 27 Oct 2009

Waskar Morris, Landis Gary N, Shen Jie, Curtis Christina, Tozer Kevin, Abdueva Diana, Skvortsov Dmitriy, Tavaré Simon, Tower John

Abstract excerpt

Truncated and mutant forms ofp53 affect life span in Drosophila, nematodes and mice, however the role of wild-type p53 in aging remains unclear. Here conditional over-expression of both wild-type and mutant p53 transgenes indicated that, in adult flies, p53 limits life span in females but favors...

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Identifiers

PMID: 20157574
DOI: 10.18632/aging.100099
PMCID: PMC2815744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20157574-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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