Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insights on Biology and Pathology of HIF-1α/-2α, TGFβ/BMP, Wnt/β-Catenin, and NF-κB Pathways in Osteoarthritis

1 May 2012

Abstract excerpt

Osteoarthritis (OA) constitutes a major health problem. Different signaling pathways are involved that impair homeostasis, but the cross-talk between them (although well investigated and partly understood), remains unclear. HIF-1α promotes chondrocyte differentiation and survival, while HIF-2α coactivates with β-catenin and NF-κB pathways to promote chondrocyte apoptosis and endochondral ossification. Depending...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Inflammatory mediators and NSAID effects
Share to Osteoarthritis Treatment and Mechanisms
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22646092
DOI: 10.2174/1381612811209023293

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insights on Biology and Pathology of HIF-1α/-2α, TGFβ/BMP, Wnt/β-Catenin, and NF-κB Pathways in OsteoarthritisPMID 22646092Read ↗

TGFβ/BMP Signaling Pathway in Cartilage HomeostasisSemantic proximity Read ↗

Role of Signal Transduction Pathways and Transcription Factors in Cartilage and Joint DiseasesSemantic proximity Read ↗

NF-κB Signaling Pathways in Osteoarthritic Cartilage DestructionSemantic proximity Read ↗

Deficiency of Cbfβ in articular cartilage leads to osteoarthritis-like phenotype through Hippo/Yap, TGFβ, and Wnt/β-catenin signaling pathways.Semantic proximity Read ↗

NF-&#954;B Signaling: Multiple Angles to Target OASemantic proximity Read ↗

Role of Signal Transduction Pathways and Transcription Factors in Cartilage and Joint DiseasesSemantic proximity Read ↗

The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and diseaseSemantic proximity Read ↗

A role for age-related changes in TGFβ signaling in aberrant chondrocyte differentiation and osteoarthritisSemantic proximity Read ↗

The involvement of signaling pathways in the pathogenesis of osteoarthritis: An updateSemantic proximity Read ↗

Multifaceted signaling regulators of chondrogenesis: Implications in cartilage regeneration and tissue engineeringSemantic proximity Read ↗

Cbfβ regulates Wnt/β-catenin, Hippo/Yap, and TGFβ signaling pathways in articular cartilage homeostasis and protects from ACLT surgery-induced osteoarthritisSemantic proximity Read ↗

TGFβ signaling in cartilage development and maintenanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.