Article
Identification of Transcription Factors Responsible for a Transforming Growth Factor-β-Driven Hypertrophy-like Phenotype in Human Osteoarthritic Chondrocytes.
Cells - 5 Apr 2022
Thielen Nathalie G M, Neefjes Margot, Vitters Elly L, van Beuningen Henk M, Blom Arjen B, Koenders Marije I, van Lent Peter L E M, van de Loo Fons A J, Blaney Davidson Esmeralda N, van Caam Arjan P M, van der Kraan Peter M
Abstract excerpt
During osteoarthritis (OA), hypertrophy-like chondrocytes contribute to the disease process. TGF-β's signaling pathways can contribute to a hypertrophy(-like) phenotype in chondrocytes, especially at high doses of TGF-β. In this study, we examine which transcription factors (TFs) are activated and involved in TGF-β-dependent induction of a hypertrophy-like phenotype in human OA chondrocytes. We found that TGF-β,...
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