A functional polymorphism (-603A --> G) in the tissue factor gene promoter is associated with adult-onset asthma.

doi:10.1038/jhg.2010.4

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Article

A functional polymorphism (-603A --> G) in the tissue factor gene promoter is associated with adult-onset asthma.

Journal of human genetics - 1 Mar 2010

Isada Akira, Konno Satoshi, Hizawa Nobuyuki, Tamari Mayumi, Hirota Tomomitsu, Harada Michishige, Maeda Yukiko, Hattori Takeshi, Takahashi Ayumu, Nishimura Masaharu

Abstract excerpt

Tissue factor (TF) is important for initiation of coagulation and for the increased thrombin activity observed at sites of inflammation. Thrombin activity is induced by allergen challenge in asthmatic airways and is involved in the pathogenesis of asthma. A -603A --> G polymorphism (rs1361600) in...

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PMID: 20150920
DOI: 10.1038/jhg.2010.4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20150920-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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