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Article

A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeast.

PLoS genetics - 5 Feb 2010

Subramanian Lakxmi, Nakamura Toru M

Abstract excerpt

ATM and ATR are two redundant checkpoint kinases essential for the stable maintenance of telomeres in eukaryotes. Previous studies have established that MRN (Mre11-Rad50-Nbs1) and ATRIP (ATR Interacting Protein) interact with ATM and ATR, respectively, and recruit their partner kinases to sites of DNA damage. Here, we investigated how Tel1(ATM) and Rad3(ATR) recruitment to telomeres is regulated in fission yeast....

Topics

Cell Cycle Proteins
Checkpoint Kinase 2
Chromosomal Proteins, Non-Histone
Models, Biological
Mutation
Protein Binding
Protein Kinases
Protein Serine-Threonine Kinases
Protein Structure, Tertiary
Protein Subunits

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Schizosaccharomyces

Schizosaccharomyces pombe Proteins

Telomere

Source

Open in PubMed Open full text

Identifiers

PMID: 20140190
DOI: 10.1371/journal.pgen.1000839
PMCID: PMC2816689

Genes

ATM
ATR
ATRIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeast.PMID 20140190Read ↗

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