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Expression of mutant RPA in human cancer cells causes telomere shortening.

Bioscience, biotechnology, and biochemistry - 1 Jan 2010

Kobayashi Yuka, Sato Koichiro, Kibe Tatsuya, Seimiya Hiroyuki, Nakamura Asako, Yukawa Masashi, Tsuchiya Eiko, Ueno Masaru

Abstract excerpt

Replication protein A (RPA) binds to single-stranded DNA generated during DNA replication and other processes. The roles of RPA in telomere maintenance have been demonstrated in yeasts, but not in telomerase-positive human cells. In this study, we found that expression of mutant RPA70 in human ce...

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Identifiers

PMID: 20139621
DOI: 10.1271/bbb.90496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20139621-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Expression of mutant RPA in human cancer cells causes telomere shortening.PMID 20139621Read ↗

Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeresSemantic proximity Read ↗

Functions of human replication protein A (RPA): From DNA replication to DNA damage and stress responsesSemantic proximity Read ↗

Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescueSemantic proximity Read ↗

Human Replication Protein A complex is a Telomerase Processivity Factor Essential for Telomere MaintenanceSemantic proximity Read ↗

Functional characterization of a cancer causing mutation in human replication protein A.Semantic proximity Read ↗

Replication protein A binds RNA and promotes R-loop formationSemantic proximity Read ↗

RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends.Semantic proximity Read ↗

Cellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpoints.Semantic proximity Read ↗

A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression.Semantic proximity Read ↗

Heterozygous RPA2 variant as a novel genetic cause of telomere biology disorders.Semantic proximity Read ↗

Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance.Semantic proximity Read ↗

Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss.Semantic proximity Read ↗

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