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Article

c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway.

The Journal of biological chemistry - 2 Apr 2010

Thien Christine B F, Dagger Samantha A, Steer James H, Koentgen Frank, Jansen Elisa S, Scott Clare L, Langdon Wallace Y

Abstract excerpt

The ability of thymocytes to assess T cell receptor (TCR) signaling strength and initiate the appropriate downstream response is crucial for determining their fate. We have previously shown that a c-Cbl RING finger mutant knock-in mouse, in which the E3 ubiquitin ligase activity of c-Cbl is inact...

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Identifiers

PMID: 20133944
DOI: 10.1074/jbc.M109.094920
PMCID: PMC2856302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20133944-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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