Article
Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency.
Cancer cell - 1 Feb 2004
Kang-Decker Ningling, Tong Caili, Boussouar Fayçal, Baker Darren J, Xu Wu, Leontovich Alexey A, Taylor William R, Brindle Paul K, van Deursen Jan M A
Abstract excerpt
CBP can function as a tumor suppressor, but the mechanisms that govern oncogenesis in its absence are unknown. Here we show that CBP inactivation in mouse thymocytes leads to lymphoma. Although CBP has been implicated in the transactivation functions of p53, development of these tumors does not seem to involve loss of p53 activity. CBP-null tumors show reduced levels of p27Kip1 and increased levels of cyclin E...
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